A Multi-state Model of the CaMKII Holoenzyme using MCell 3.3

10.4231/MV0Z-8Z57

Matthew C Pharris , Tamara L Kinzer-Ursem

07/29/2019

This model uses a specialized rule-based syntax in MCell 3.3 to model the twelve-subunit CaMKII holoenzyme without inducing combinatorial explosion. The model allows us to explore the regulation of CaMKII activation and autophosphorylation.

Biomedical Engineering Calcium Calmodulin Computational Modeling Kinase Neuroscience Protein Signaling Rule-Based Modeling Synaptic Plasticity