Piezo regulates epithelial topology and promotes precision in organ size control

• Mayesha Mim Jeremiah Zartman

  01/14/2025

  Mim et al. show that Piezo regulates organ size and cell topology by controlling cell tension, cell division, death, and tissue properties both locally and non-locally. Piezo ensures precise organ growth by regulating cellular processes and tissue architec...

• Keywords:

  morphogenesis calcium cell cycle fluctuating asymmetry

• OMERO:

  morphogenesis calcium cell cycle fluctuating asymmetry

Reverse engineering morphogenesis through Bayesian optimization of physics-based models

• Nilay Kumar, Mayesha Mim Alexander Dowling, Jeremiah Zartman

  01/23/2025

  Morphogenetic programs coordinate cell signaling and mechanical interactions to shape organs. In systems and synthetic biology, a key challenge is determining optimal cellular interactions for predicting organ shape, size, and function. Physics-based model...

• Keywords:

  Bayesian optimization morphogenesis mechanotransduction extracellular matrix