Piezo regulates epithelial topology and promotes precision in organ size control
Mayesha Mim, Jeremiah Zartman
01/14/2025
Mim et al. show that Piezo regulates organ size and cell topology by controlling cell tension, cell division, death, and tissue properties both locally and non-locally. Piezo ensures precise organ growth by regulating cellular processes and tissue architec...
Keywords:
morphogenesis calcium cell cycle fluctuating asymmetry
OMERO:
morphogenesis calcium cell cycle fluctuating asymmetry
Calcium Imaging in Drosophila Organs
David Gazzo, Jeremiah Zartman
01/17/2025
Ex vivo calcium imaging in Drosophila opens an expansive amount of research avenues for the study of live signal propagation through complex tissue. Here, we describe how to isolate Drosophila organs of interest, like the developing wing imaginal disc and...
Keywords:
calcium imaging calcium dynamics Drosophila Ex vivo Microfluidics
Weiwei Zhang, Nilay Kumar, Jessica Helwig, Alexis Hoerter, Anjali Iyer-Pascuzzi, David Umulis, Elsje Pienaar, Christopher Staiger
03/04/2025
Cytosolic Ca2+ signatures with specific spatiotemporal patterns play crucial roles in plant responses to biotic and abiotic stresses. When plants detect microbial signals or damage, they trigger the first layer of defense against pathogens known as pattern...
Keywords:
cytosolic calcium initiator cells pattern-triggered immunity plant defense response signal transduction traveling wave
Reverse engineering morphogenesis through Bayesian optimization of physics-based models
Nilay Kumar, Mayesha Mim, Alexander Dowling, Jeremiah Zartman
01/23/2025
Morphogenetic programs coordinate cell signaling and mechanical interactions to shape organs. In systems and synthetic biology, a key challenge is determining optimal cellular interactions for predicting organ shape, size, and function. Physics-based model...
Keywords:
Bayesian optimization morphogenesis mechanotransduction extracellular matrix
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