Piezo regulates epithelial topology and promotes precision in organ size control

• Mayesha Mim, Jeremiah Zartman

  01/14/2025

  Mim et al. show that Piezo regulates organ size and cell topology by controlling cell tension, cell division, death, and tissue properties both locally and non-locally. Piezo ensures precise organ growth by regulating cellular processes and tissue architec...

• Keywords:

  morphogenesis calcium cell cycle fluctuating asymmetry

• OMERO:

  morphogenesis calcium cell cycle fluctuating asymmetry

Calcium Imaging in Drosophila Organs

• David Gazzo, Jeremiah Zartman

  01/17/2025

  Ex vivo calcium imaging in Drosophila opens an expansive amount of research avenues for the study of live signal propagation through complex tissue. Here, we describe how to isolate Drosophila organs of interest, like the developing wing imaginal disc and...

• Keywords:

  calcium imaging calcium dynamics Drosophila Ex vivo Microfluidics

Reverse engineering morphogenesis through Bayesian optimization of physics-based models

• Nilay Kumar, Mayesha Mim, Alexander Dowling, Jeremiah Zartman

  01/23/2025

  Morphogenetic programs coordinate cell signaling and mechanical interactions to shape organs. In systems and synthetic biology, a key challenge is determining optimal cellular interactions for predicting organ shape, size, and function. Physics-based model...

• Keywords:

  Bayesian optimization morphogenesis mechanotransduction extracellular matrix